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Published Online: 12 May 2020

Pharmacological Effects of 1′-Acetoxychavicol Acetate, a Major Constituent in the Rhizomes of Alpinia galanga and Alpinia conchigera

Publication: Journal of Medicinal Food
Volume 23, Issue Number 5

Abstract

1′-Acetoxychavicol acetate (ACA) is found in the rhizomes or seeds of Alpinia galanga and Alpinia conchigera, which are used as traditional spices in cooking and traditional medicines in Southeast Asia. ACA possesses numerous medicinal properties. Those include anticancer, antiobesity, antiallergy, antimicrobial, antidiabetic, gastroprotective, and anti-inflammatory activities. ACA is also observed to exhibit antidementia activity. Recent studies have demonstrated that combining ACA with other substances results in synergistic anticancer effects. The structural factors that regulate the activity of ACA include (1) the acetyl group at position 1′, (2) the acetyl group at position 4, and (3) the unsaturated double bond between positions 2′ and 3′. ACA induces the activation of AMP-activated protein kinase (AMPK), which regulates the signal transduction pathways, and has an important role in the prevention of diseases, including cancer, obesity, hyperlipidemia, diabetes, and neurodegenerative disorders. Such findings suggest that AMPK has a central role in different pharmacological functions of ACA, and ACA is useful for the prevention of life-threatening diseases. However, more studies should be performed to evaluate the clinical effects of ACA and to better understand its potential.

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Published In

cover image Journal of Medicinal Food
Journal of Medicinal Food
Volume 23Issue Number 5May 2020
Pages: 465 - 475
PubMed: 32069429

History

Published online: 12 May 2020
Published in print: May 2020
Published ahead of print: 18 February 2020
Accepted: 9 January 2020
Received: 20 May 2019

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Akiko Kojima-Yuasa [email protected]
Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, Osaka, Japan.
Isao Matsui-Yuasa
Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, Osaka, Japan.

Notes

Address correspondence to: Akiko Kojima-Yuasa, PhD, Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, Osaka 558-8585, Japan. [email protected]

Author Disclosure Statement

No competing financial interest exists.

Funding Information

This work was supported by JSPS KAKENHI (Grant Nos. JP 24500987 and JP15K00832).

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