Hair Follicle Regeneration in Skin Grafts: Current Concepts and Future Perspectives
Publication: Tissue Engineering Part B: Reviews
Volume 18, Issue Number 1
Abstract
The repair and management of full-thickness skin defects resulting from burns and chronic wounds remain a significant unmet clinical challenge. For those skin defects exceeding 50%–60% of total body surface area, it is impractical to treat with autologous skin transplants because of the shortage of donor sites. The possibility of using tissue-engineered skin grafts for full-thickness wound repair is a promising approach. The primary goal of tissue-engineered skin grafts is to restore lost barrier function, but regeneration of appendages, such as hair follicles, has to be yet achieved. The successful regeneration of hair follicles in immunodeficient mice suggests that creating human hair follicles in tissue-engineered skin grafts is feasible. However, many limitations still need to be explored, particularly enriching isolated cells with trichogenic capacity, maintaining this ability during processing, and providing the cells with proper environmental cues. Current advances in hair follicle regeneration, in vitro and in vivo, are concisely summarized in this report, and key requirements to bioengineer a hair follicle are proposed, with emphasis on a three-dimensional approach.
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Information & Authors
Information
Published In
Tissue Engineering Part B: Reviews
Volume 18 • Issue Number 1 • February 2012
Pages: 15 - 23
PubMed: 21883016
Copyright
Copyright 2012, Mary Ann Liebert, Inc.
History
Published in print: February 2012
Published ahead of print: 1 September 2011
Published online: 31 August 2011
Accepted: 5 July 2011
Received: 2 February 2011
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No competing financial interests exist.
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