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Cover Credit: This issue of Thyroid contains four reviews covering important contributions from Japan. The cover illustration, entitled “thyroid” in Japanese, reflects the included topics.

Upper left panel: In the Japanese quail (Coturnix japonica), gonadotropin releasing hormone (GnRH) secretion and gonadal size is regulated in a seasonal fashion by an alternative form of thyroid stimulating hormone (TSH) secreted by the pars tuberalis of the pituitary gland and T3 produced in the mediobasal hypothalamus. These seminal insights define this distinct form of TSH as a “springtime hormone” and provide fundamental insights into seasonal regulation of reproduction.

1. Nakayama T, Yoshimura T 2018 Seasonal Rhythms: The Role of Thyrotropin and Thyroid Hormones. Thyroid: 28(1): 4–10, 2018.

Upper right panel: A papillary thyroid microcarcinoma on ultrasound. Longitudinal studies initiated in the 1990s in Japan have demonstrated that the vast majority of papillary thyroid microcarcinomas have an indolent behavior and that active surveillance may be an alternative approach in many patients. The challenge that lies ahead of us is to identify the small group of patients with papillary thyroid microcarcinomas that require active intervention.

2. Miyauchi A, Ito Y, Oda H 2018 Insights into the Management of Papillary Microcarcinoma of the Thyroid. Thyroid 28(1): 23–31, 2018.

Lower left panel: Thyroid storm. Severe thyrotoxicosis, commonly referred to as “thyroid storm” is a challenging clinical entity. Recent clinical research from Japan has aimed at better defining the diagnostic criteria and management recommendations for thyroid storm.

3. Akamizu T 2018 Thyroid Storm: A Japanese Perspective. Thyroid 28(1): 32–40, 2018.

Lower right panel: The Fukushima Daiichi Nuclear Power Plant after the Great East Japan Earthquake followed by the giant tsunami on March 11th, in 2011. Longitudinal studies are addressing the potential health and societal consequences of the nuclear accident in Fukushima. This includes screening of the population for thyroid malignancies. This review discusses the current results, public health perspectives and challenges associated with screening.

4. Yamashita S, Suzuki S, Suzuki S, Shimura H, Saenko V 2018 Lessons from Fukushima: Latest Findings of Thyroid Cancer After the Fukushima Nuclear Power Plant Accident. Thyroid 28(1): 11–22, 2018.


Thyroid Editor-in-Chief: Anna M. Sawka, MD, PhD
Clinical Thyroidology Editor-in-Chief: Trevor E. Angell, MD
VideoEndocrinology Editor-in-Chief: Catherine F. Sinclair, MD, FRACS
ISSN: 1050-7256 Online ISSN: 1557-9077 Published MonthlyCurrent Volume: 34
Impact Factor: 6.6* *2022 Journal Citation Reports™ (Clarivate, 2023)
The definitive peer-reviewed journal package in thyroid disease, care, and research, providing multidisciplinary original research and patient-focused reports, reviews and commentary, and an innovative videojournal companion covering new surgical and diagnostic imaging techniques and technologies.

Volume 28, Issue 1 / January 2018

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